DEEP SEQUENCE-COUPLED BIOPANNING
Working in close collaboration with Dr. Bryce Chackerian and Dr. David Peabody at the University of New Mexico, the Frietze Lab has developed a novel technology for investigating the specificity of antibodies in serum from humans. This technology has been used to investigate antibody responses to Dengue virus, Chlamydia trachomatis, and ovarian cancer.
Frietze KM, Roden RB, Lee JH, Shi Y, Peabody DS, Chackerian B. Identification of Anti-CA125 Antibody Responses in Ovarian Cancer Patients by a Novel Deep Sequence-Coupled Biopanning Platform. Cancer Immunol Res. 2016 Feb;4(2):157-64. PMCID: PMC4740227.
Frietze KM, Pascale JM, Moreno B, Chackerian B, Peabody DS. Pathogen-specific deep sequence-coupled biopanning: A method for surveying human antibody responses. PLoS One. 2017 Feb 2;12(2):e0171511. PMCID: PMC5289605.